HrpA, a DEAH-Box RNA Helicase, Is Involved in Global Gene Regulation in the Lyme Disease Spirochete
| Title | HrpA, a DEAH-Box RNA Helicase, Is Involved in Global Gene Regulation in the Lyme Disease Spirochete |
| Publication Type | Journal Article |
| Year of Publication | 2011 |
| Journal | PloS One |
| Volume | 6 |
| Issue | 7 |
| Start Page | 22168 |
| Authors | Salman-Dilgimen A, Hardy PO, Dresser AR, Chaconas G |
| Keywords | bacteria, biology, borrelia, burgdorferi, disease, lyme |
| Abstract | In this work on the Lyme spirochete, B. burgdorferi, we show that a disruption of the hrpA gene, which encodes a putative RNA helicase, results in a complete loss in the ability of the spirochetes to infect mice by needle inoculation. |
| URL | http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0022168 |
| DOI | 10.1371/journal.pone.0022168 |
