Pharmacokinetics of imidocarb dipropionate in white‐tailed deer (Odocoileus virginianus) after single intramuscular administration

Author:

Milnes, EL, Delnatte, P, Woodbury, M, Hering, A, Lee, S, Smith, DA, Nemeth, NM, Gu, Y, Gehring, R, and Johnson, R

Publication type:

Journal Article

Publication date:

2019-01

Journal/Series title:

J Vet Pharmacol and Therap

Volume:

URL:

https://onlinelibrary.wiley.com/doi/10.1111/jvp.12760

Abstract:

This study was designed to investigate the pharmacokinetics of imidocarb, a carbanilide derivative, in white‐tailed deer (Odocoileus virginianus). The pharmacokinetic properties of a single intramuscular (IM) dose of imidocarb were determined in 10 deer. A single IM injection of 3.0 mg/kg imidocarb dipropionate was administered, and blood samples were collected prior to, and up to 48 hr after imidocarb administration. Plasma imidocarb concentrations were determined by high‐performance liquid chromatography with ultraviolet detection. The disposition of plasma imidocarb was best characterized by a two‐compartment open model.