Modified two-tiered testing algorithm for Lyme disease serology: The Canadian context

TitleModified two-tiered testing algorithm for Lyme disease serology: The Canadian context
Publication TypeJournal Article
Year of Publication2020
AuthorsHatchette TF, Lindsay LR
JournalCan Commun Dis Rep
Volume46
Start Page125
Issue5
Pagination125-131
Date Published05/2020
Keywordsborrelia burgdorferi, diagnostics, enzyme immunoassays, immunoblots, Lyme disease, serology, standard two-tiered testing
Abstract

Diagnostic improvements in sensitivity of LD testing without significant loss of specificity have been consistently reported when MTTT is compared with STTT in studies conducted in highly LD endemic regions. Our working group agrees with the recommendation by the United States Centers for Disease Control that serological testing for LD using MTTT is an acceptable alternative to STTT. This recommendation is contingent on development and implementation of comprehensive validation studies on the performance of MTTT vs STTT within the Canadian context, including evaluation of the test performance in areas of low endemicity for LD.

URLhttps://www.canada.ca/content/dam/phac-aspc/documents/services/reports-publications/canada-communicable-disease-report-ccdr/monthly-issue/2020-46/issue-5-may-7-2020/ccdrv46i05a05-eng.pdf