Invariant natural killer T cells act as an extravascular cytotoxic barrier for joint-invading Lyme Borrelia.
Title | Invariant natural killer T cells act as an extravascular cytotoxic barrier for joint-invading Lyme Borrelia. |
Publication Type | Journal Article |
Year of Publication | 2014 |
Journal | Proc Natl Acad Sci U S A |
Volume | 111 |
Issue | 38 |
Start Page | 13936 |
Date Published | 09/2014 |
Authors | Lee WY, Sanz MJ, Wong CH, Hardy PO, Salman-Dilgimen A, Moriarty TJ, Chaconas G, Marques A, Krawetz R, Mody CH, Kubes P |
Keywords | granzyme B, joint iNKT cells, Lyme arthritis |
Abstract | Successful penetrance of B. burgdorferi out of the vasculature and into the joint tissue was met by a lethal attack by extravascular iNKT cells through a granzyme-dependent pathway, an observation also made in vitro for iNKT cells from joint but not liver or spleen. These results suggest a novel, critical extravascular iNKT cell immune surveillance in joints that functions as a cytotoxic barrier and explains a large increase in pathogen burden of B. burgdorferi in the joint of iNKT cell-deficient mice, and perhaps the greater susceptibility of humans to this pathogen because of fewer iNKT cells in human joints. |
URL | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4183287/ |
DOI | 10.1073/pnas.1404769111 |