Hyperglycemia Impairs Neutrophil-Mediated Bacterial Clearance in Mice Infected with the Lyme Disease Pathogen
| Title | Hyperglycemia Impairs Neutrophil-Mediated Bacterial Clearance in Mice Infected with the Lyme Disease Pathogen |
| Publication Type | Journal Article |
| Year of Publication | 2016 |
| Journal | PLoS One |
| Volume | 11 |
| Issue | 6 |
| Start Page | e0158019 |
| Date Published | 06/2016 |
| Authors | Javid A, Zlotnikov N, Pětrošová H, Tang T, Zhang Y, Bansal AK, Ebady R, Parikh M, Glogauer M, Moriarty TJ, Mijhgan A, Kim YR, Sosa MS, Sun C, Newbiggin S |
| Keywords | bacteria, borrelia, burgdorferi, diabetes, lyme, mice, neutrophils |
| Abstract | The present study investigated the impact of sustained obesity-independent hyperglycemia in mice on bacterial clearance, inflammatory pathology and neutrophil responses to B. burgdorferi. These data suggest that investigating the effects of comorbid conditions such as diabetes on outcomes of B. burgdorferi infections in humans may be warranted. |
| URL | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4920391/ |
